Sertad3^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sertad3^em1Bcgen
• Name: SERTA domain containing 3; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:6502863
• Synonyms: Sertad3^-
• Gene: Sertad3 Location: Chr7:27173265-27176789 bp, + strand Genetic Position: Chr7, 15.91 cM
• Alliance: Sertad3^em1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Two sgRNAs, targeting the 5' UTR and the 3' UTR, were used with CRISPR/Cas9 technology. (J:300469)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sertad3 Mutation: 14 strains or lines available

References

• Original: J:300469 Sun N, et al., Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex. Cell Rep. 2020 Nov 3;33(5):108342
• All: 1 reference(s)