Eps15l1^tm1.1Noff
Targeted Allele Detail

Summary

• Symbol: Eps15l1^tm1.1Noff
• Name: epidermal growth factor receptor pathway substrate 15-like 1; targeted mutation 1.1, Nina Offenhauser
• MGI ID: MGI:6505484
• Synonyms: Eps15L1-KO
• Gene: Eps15l1 Location: Chr8:73094843-73175304 bp, - strand Genetic Position: Chr8, 35.02 cM, cytoband C1
• Alliance: Eps15l1^tm1.1Noff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272122
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeted locus contains a PGK-neo cassette flanked by two FRT sites and two LoxP sites at the limits of the region to be excised. The region to be deleted contains the first exon and its upstream region. The first exon and the PGK-neo cassette were removed by crossing with general deleter Cre mice. Western blot analysis confirmed the absence of protein expression in brain lysates from newborn homozygous mutant mice. (J:272122)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eps15l1 Mutation: 80 strains or lines available

References

• Original: J:272122 Milesi C, et al., Redundant and nonredundant organismal functions of EPS15 and EPS15L1. Life Sci Alliance. 2019 Feb;2(1)
• All: 1 reference(s)