Gsg1l^tm1.2Tern
Targeted Allele Detail

Summary

• Symbol: Gsg1l^tm1.2Tern
• Name: GSG1-like; targeted mutation 1.2, Terunaga Nakagawa
• MGI ID: MGI:6505615
• Synonyms: GSG1L^-
• Gene: Gsg1l Location: Chr7:125477592-125681583 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Gsg1l^tm1.2Tern page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301313
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 3 and the following elements into intron 4: an FRT site, a second loxP site, engrailed homeobox 2 (en2) intron and splice acceptor sequences, IRES sequence, the tdTomato red fluorescent protein gene with sequence for a C-terminal HA tag, poly(A) signal sequence, a neomycin resistance gene cassette, a second FRT site and a third loxP site. The sequence between the FRT sites (RFP and neo cassettes) were removed through subsequent flp-mediated recombination. Exon 4 was then deleted through cre-mediated recombination. (J:301313)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsg1l Mutation: 15 strains or lines available

References

• Original: J:301313 Kamalova A, et al., AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility. Cell Rep. 2020 Jul 21;32(3):107921
• All: 1 reference(s)