Tubb2a^em2Rstot
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tubb2a^em2Rstot
• Name: tubulin, beta 2A class IIA; endonuclease-mediated mutation 2, Rolf Stottmann
• MGI ID: MGI:6506265
• Synonyms: Tubb2a^d4222
• Gene: Tubb2a Location: Chr13:34258261-34261991 bp, - strand Genetic Position: Chr13, 14.03 cM
• Alliance: Tubb2a^em2Rstot page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 4,222 bp deletion encompassing the genomic region Chr13:34,074,225-34,078,446 (GRCm38/mm10). (J:278765)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tubb2a Mutation: 27 strains or lines available

References

• Original: J:278765 Bittermann E, et al., Differential requirements of tubulin genes in mammalian forebrain development. PLoS Genet. 2019 Aug;15(8):e1008243
• All: 1 reference(s)