Tuba1a^em2Rstot
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tuba1a^em2Rstot
• Name: tubulin, alpha 1A; endonuclease-mediated mutation 2, Rolf Stottmann
• MGI ID: MGI:6506268
• Synonyms: Tuba1a^d4262
• Gene: Tuba1a Location: Chr15:98847728-98851382 bp, - strand Genetic Position: Chr15, 55.29 cM
• Alliance: Tuba1a^em2Rstot page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 4,262 bp deletion encompassing the genomic region Chr15:98,949,770-98,954,031 (GRCm38/mm10). (J:278765)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tuba1a Mutation: 15 strains or lines available

References

• Original: J:278765 Bittermann E, et al., Differential requirements of tubulin genes in mammalian forebrain development. PLoS Genet. 2019 Aug;15(8):e1008243
• All: 1 reference(s)