Uox^em1Cli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Uox^em1Cli
• Name: urate oxidase; endonuclease-mediated mutation 1, Changgui Li
• MGI ID: MGI:6506271
• Gene: Uox Location: Chr3:146302904-146337238 bp, + strand Genetic Position: Chr3, 72.09 cM
• Alliance: Uox^em1Cli page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• TALEN technology generated a 28 base pair deletion in exon 3. (J:271949)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uox Mutation: 34 strains or lines available

References

• Original: J:271949 Lu J, et al., Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders. Kidney Int. 2018 Jan;93(1):69-80
• All: 5 reference(s)