Syn1^{em1(cre/ERT2)Iiis}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Syn1^{em1(cre/ERT2)Iiis}
• Name: synapsin I; endonuclease-mediated mutation 1, Masashi Yanagisawa and Hiromasa Funato
• MGI ID: MGI:6506975
• Synonyms: synapsin1^CreERT2
• Gene: Syn1 Location: ChrX:20726750-20787157 bp, - strand Genetic Position: ChrX, 16.37 cM, cytoband A1-A4
• Alliance: Syn1^{em1(cre/ERT2)Iiis} page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Syn1^{em1(cre/ERT2)Iiis} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Syn1 (MGI:98460)

• CRISPR-targeting introduced an IRES-iCreERT2 sequence 22 bp downstream of the stop codon. (J:301630)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Syn1 (mouse) Summary of all recombinase alleles driven by Syn1. Comparative matrix view of recombinase activities Alliance mouse Syn1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syn1 Mutation: 22 strains or lines available

References

• Original: J:301630 Iwasaki K, et al., Induction of mutant Sik3Sleepy allele in neurons in late infancy increases sleep need. J Neurosci. 2021
• All: 2 reference(s)