Nkg7^em1(cre)Wehi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nkg7^em1(cre)Wehi
• Name: natural killer cell group 7 sequence; endonuclease-mediated mutation 1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:6506977
• Synonyms: Nkg7-cre
• Gene: Nkg7 Location: Chr7:43086562-43087670 bp, + strand Genetic Position: Chr7, 28.25 cM, cytoband B2
• Alliance: Nkg7^em1(cre)Wehi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Nkg7^em1(cre)Wehi expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkg7 (MGI:1931250)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a cre gene into the endogenous Nkg7 gene. Cre recombinase is expressed under the control of the endogenous gene promoter. (J:301637)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkg7 (mouse) Summary of all recombinase alleles driven by Nkg7. Alliance mouse Nkg7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkg7 Mutation: 14 strains or lines available

References

• Original: J:301637 Ng SS, et al., The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nat Immunol. 2020 Oct;21(10):1205-1218
• All: 1 reference(s)