Phf6^tm1.1Avo
Targeted Allele Detail

Summary

• Symbol: Phf6^tm1.1Avo
• Name: PHD finger protein 6; targeted mutation 1.1, Anne K Voss
• MGI ID: MGI:6507034
• Synonyms: Phf6^lox
• Gene: Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
• Alliance: Phf6^tm1.1Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276228
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT-flanked neomycin phosphotransferase expression cassette followed by a second loxP site were inserted downstream of exon 5. The neomycin cassette was removed via Flp-mediated recombination leaving exons 4-5 floxed. (J:276228)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Phf6 Mutation: 12 strains or lines available

References

• Original: J:276228 McRae HM, et al., PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia. Blood. 2019 Apr 18;133(16):1729-1741
• All: 4 reference(s)