Phf6^tm1.2Avo
Targeted Allele Detail

Summary

• Symbol: Phf6^tm1.2Avo
• Name: PHD finger protein 6; targeted mutation 1.2, Anne K Voss
• MGI ID: MGI:6507035
• Gene: Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
• Alliance: Phf6^tm1.2Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276228
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT-flanked neomycin selection cassette followed by a second loxP site were inserted downstream of exon 5. The neomycin cassette was removed via Flp-mediated recombination. Exons 4 and 5 were removed via cre-mediated recombination. (J:276228)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phf6 Mutation: 12 strains or lines available

References

• Original: J:276228 McRae HM, et al., PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia. Blood. 2019 Apr 18;133(16):1729-1741
• All: 2 reference(s)