Tg(DMD*)#Spc
Transgene Detail

Summary

• Symbol: Tg(DMD*)#Spc
• Name: transgene insertion, Melissa J Spencer
• MGI ID: MGI:6507847
• Synonyms: hDMD del45
• Transgene: Tg(DMD*)#Spc Location: unknown
• Alliance: Tg(DMD*)#Spc page

Mutation origin

• Strain of Origin: STOCK Tg(DMD)72Thoen/J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(DMD*)#Spc expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DMD (1756)

  Dmd	(MGI:94909)

  Exon 45 is deleted

• Mutation details: CRISPR/Cas9 technology generated a deletion of exon 45 of the human DMD in Tg(DMD)72Thoen mice. Two founders were used to establish lines, however the pound symbol (#) is used when line is not specified and/or lines are pooled. The transgene integrated on chromosome 5 in a tail to tail duplication. (J:280218)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:280218 Young CS, et al., Creation of a Novel Humanized Dystrophic Mouse Model of Duchenne Muscular Dystrophy and Application of a CRISPR/Cas9 Gene Editing Therapy. J Neuromuscul Dis. 2017;4(2):139-145
• All: 1 reference(s)