Dsg2^tm3.1Leu
Targeted Allele Detail

Summary

• Symbol: Dsg2^tm3.1Leu
• Name: desmoglein 2; targeted mutation 3.1, Rudolf E Leube
• MGI ID: MGI:6508032
• Synonyms: DSG2^fl, DSG2^flox(E4-5)
• Gene: Dsg2 Location: Chr18:20691247-20737583 bp, + strand Genetic Position: Chr18, 11.42 cM
• Alliance: Dsg2^tm3.1Leu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298758
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exons 4 and 5 and an frt-flanked neomycin resistance cassette was inserted downstream of exon 5. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:298758)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dsg2 Mutation: 80 strains or lines available

References

• Original: J:298758 Kant S, et al., Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function. Circ Cardiovasc Genet. 2015 Aug;8(4):553-63
• All: 6 reference(s)