Cbarp^em1Dsb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cbarp^em1Dsb
• Name: calcium channel, voltage-dependent, beta subunit associated regulatory protein; endonuclease-mediated mutation 1, David S Bredt
• MGI ID: MGI:6508393
• Synonyms: BARP KO
• Gene: Cbarp Location: Chr10:79966268-79976189 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Cbarp^em1Dsb page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The molecular lesion is described as a 6-base pair deletion and 1 base pair insertion (T) at 2970 (no reference sequence given). Western blot analysis confirmed the complete loss of protein in brain lysates from knockout mice. (J:288382)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbarp Mutation: 22 strains or lines available

References

• Original: J:288382 Gu S, et al., alpha6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Rep. 2019 Jan 22;26(4):866-874.e3
• All: 2 reference(s)