Lypd8^tm2Ktak
Targeted Allele Detail

Summary

• Symbol: Lypd8^tm2Ktak
• Name: LY6/PLAUR domain containing 8; targeted mutation 2, Kiyoshi Takeda
• MGI ID: MGI:6508395
• Synonyms: Lypd8^-
• Gene: Lypd8 Location: Chr11:58269869-58281365 bp, + strand Genetic Position: Chr11, 36.19 cM, cytoband B2
• Alliance: Lypd8^tm2Ktak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232706
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of genomic fragment containing the third and fourth exons of the gene with a loxP-flanked neomycin-resistance gene cassette. Quantitative RT-PCR analysis revealed that Lypd8 expression is significantly reduced in the colon of homozygous mutant mice. (J:232706)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lypd8 Mutation: 22 strains or lines available

References

• Original: J:232706 Okumura R, et al., Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature. 2016 Apr 7;532(7597):117-21
• All: 3 reference(s)