Bin2^tm1.1Beni
Targeted Allele Detail

Summary

• Symbol: Bin2^tm1.1Beni
• Name: bridging integrator 2; targeted mutation 1.1, Bernhard Nieswandt
• MGI ID: MGI:6508532
• Synonyms: Bin2^fl
• Gene: Bin2 Location: Chr15:100538963-100567384 bp, - strand Genetic Position: Chr15, 56.37 cM
• Alliance: Bin2^tm1.1Beni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302510
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and an frt-flanked neomycin selection cassette was inserted 403 bp upstream of exon 3, and a single loxP site was inserted downstream of exon 3. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:302510)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Bin2^tm1.1Beni/Bin2^tm1.1Beni Tg(Pf4-icre)Q3Rsko/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Phenotypes:

Affected Systems	cn1
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hematopoietic system	√
hematopoietic system phenotype	N
abnormal platelet calcium level	√
abnormal platelet physiology	√
abnormal platelet activation	√
decreased platelet aggregation	√
homeostasis/metabolism	√
abnormal platelet calcium level	√
abnormal platelet physiology	√
abnormal platelet activation	√
decreased platelet aggregation	√
decreased susceptibility to induced thrombosis	√
increased bleeding time	√
decreased susceptibility to ischemic brain injury	√
decreased cerebral infarct size	√
nervous system	√
decreased susceptibility to ischemic brain injury	√
decreased cerebral infarct size	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bin2 Mutation: 14 strains or lines available

References

• Original: J:302510 Volz J, et al., BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. J Clin Invest. 2020 Nov 2;130(11):6064-6079
• All: 1 reference(s)