Tgm6^em1Bge
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tgm6^em1Bge
• Name: transglutaminase 6; endonuclease-mediated mutation 1, Baoxue Ge
• MGI ID: MGI:6508555
• Gene: Tgm6 Location: Chr2:129954336-129996152 bp, + strand Genetic Position: Chr2, 63.19 cM
• Alliance: Tgm6^em1Bge page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRIPSR/Cas9 genome editing technology was used to create a deletion of 110 nucleotides located in exon 4. This lesion caused a reading frame shift and a premature stop codon. (J:268324)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgm6 Mutation: 34 strains or lines available

References

• Original: J:268324 Zheng R, et al., Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese. Nat Commun. 2018 Oct 4;9(1):4072
• All: 1 reference(s)