Scx^{tm2.1(cre/ERT2)Stzr}
Targeted Allele Detail

Summary

• Symbol: Scx^{tm2.1(cre/ERT2)Stzr}
• Name: scleraxis scleraxis bHLH transcription factor; targeted mutation 2.1, Ronen Schweitzer
• MGI ID: MGI:6508700
• Synonyms: Scx^cre/ERT2, Scx^CreERT2
• Gene: Scx Location: Chr15:76341652-76343658 bp, + strand Genetic Position: Chr15, 35.92 cM
• Alliance: Scx^{tm2.1(cre/ERT2)Stzr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268613
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Scx^{tm2.1(cre/ERT2)Stzr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scx (MGI:102934)

• Mutation details: An IRES-CreERT2 sequence was inserted between the stop codon and 3 UTR in exon 2. The construct also contained a FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the neo cassette. (J:268613, J:299624)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scx (mouse) Summary of all recombinase alleles driven by Scx. Comparative matrix view of recombinase activities Alliance mouse Scx gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scx Mutation: 15 strains or lines available

References

• Original: J:268613 Howell K, et al., Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing. Sci Rep. 2017 Mar 23;7:45238
• All: 10 reference(s)