Cx3cr1^{em1(Ccre)Jung}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cx3cr1^{em1(Ccre)Jung}
• Name: C-X3-C motif chemokine receptor 1; endonuclease-mediated mutation 1, Steffen Jung
• MGI ID: MGI:6508987
• Synonyms: Cx3cr1^ccre
• Gene: Cx3cr1 Location: Chr9:119877749-119897362 bp, - strand Genetic Position: Chr9, 71.37 cM
• Alliance: Cx3cr1^{em1(Ccre)Jung} page

Mutation origin

• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Cx3cr1^{em1(Ccre)Jung} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cx3cr1 (MGI:1333815)

• Mutation details: CRISPR/Cas9 system inserted a cassette encoding a viral 2A oligopeptide (T2A) self-cleaving peptide, that mediates ribosomal skipping, fused to an C-terminal Cre recombinase fragment (CCre), directly downstream of the chemokine (C-X3-C motif) receptor 1 (Cx3cr1) gene. (J:302588)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cx3cr1 (mouse) Summary of all recombinase alleles driven by Cx3cr1. Comparative matrix view of recombinase activities Alliance mouse Cx3cr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cx3cr1 Mutation: 45 strains or lines available

References

• Original: J:302588 Kim JS, et al., A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages. Immunity. 2021 Jan 12;54(1):176-190.e7
• All: 3 reference(s)