Sall1^{em1(Ncre)Jung}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sall1^{em1(Ncre)Jung}
• Name: spalt like transcription factor 1; endonuclease-mediated mutation 1, Steffen Jung
• MGI ID: MGI:6508988
• Synonyms: Sall1^ncre
• Gene: Sall1 Location: Chr8:89753867-89770790 bp, - strand Genetic Position: Chr8, 43.51 cM, cytoband D
• Alliance: Sall1^{em1(Ncre)Jung} page

Mutation origin

• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Sall1^{em1(Ncre)Jung} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sall1 (MGI:1889585)

• Mutation details: CRISPR/Cas9 system inserted a cassette encoding a viral 2A oligopeptide (T2A) self-cleaving peptide, that mediates ribosomal skipping, fused to an N-terminal Cre recombinase fragment (NCre), directly downstream of the spalt like transcription factor 1 (Sall1) gene. (J:302588)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sall1 (mouse) Summary of all recombinase alleles driven by Sall1. Comparative matrix view of recombinase activities Alliance mouse Sall1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sall1 Mutation: 78 strains or lines available

References

• Original: J:302588 Kim JS, et al., A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages. Immunity. 2021 Jan 12;54(1):176-190.e7
• All: 2 reference(s)