Adamdec1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Adamdec1^tm1Dgen
• Name: ADAM-like, decysin 1; targeted mutation 1, Deltagen
• MGI ID: MGI:6509014
• Gene: Adamdec1 Location: Chr14:68800829-68819535 bp, - strand Genetic Position: Chr14, 35.69 cM
• Alliance: Adamdec1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301741
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin-resistant cassette was inserted in exon 11. Quantitative PCR and Western blot analysis confirmed the absence of mRNA and protein expression. (J:301741)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamdec1 Mutation: 40 strains or lines available

References

• Original: J:301741 O'Shea NR, et al., Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation. J Crohns Colitis. 2016 Dec;10(12):1417-1427
• All: 1 reference(s)