Dsc2^tm1.1Leu
Targeted Allele Detail

Summary

• Symbol: Dsc2^tm1.1Leu
• Name: desmocollin 2; targeted mutation 1.1, Rudolf E Leube
• MGI ID: MGI:6509038
• Synonyms: Dsc2^fl
• Gene: Dsc2 Location: Chr18:20163690-20192611 bp, - strand Genetic Position: Chr18, 11.14 cM
• Alliance: Dsc2^tm1.1Leu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302333
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin selection cassette and a second loxP site into intron 2. The neo cassette was removed via flp-mediated recombination in the germline, leaving a conditional-ready allele with exon 2 floxed. (J:302593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dsc2 Mutation: 80 strains or lines available

References

• Original: J:302593 Rimpler U, Funktionelle Charakterisierung von Desmocollin 2 wahrend der Embryonalentwicklung und im adulten Herzen in der Maus. PhD Thesis - Humboldt University zu Berlin. 2014
• All: 4 reference(s)