Tspan6^tm2Vlcg
Targeted Allele Detail

Summary

• Symbol: Tspan6^tm2Vlcg
• Name: tetraspanin 6; targeted mutation 2, Velocigene
• MGI ID: MGI:6509072
• Gene: Tspan6 Location: ChrX:132791817-132799178 bp, - strand Genetic Position: ChrX, 55.47 cM, cytoband E3
• Alliance: Tspan6^tm2Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301767
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2. Western blot analysis of neuronal lysates from cortical primary cultures confirmed total absence of protein in homozygous mutant mice. (J:301767)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tspan6^tm2Vlcg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspan6 Mutation: 3 strains or lines available

References

• Original: J:301767 Salas IH, et al., Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity. PLoS One. 2017;12(2):e0171968
• All: 4 reference(s)