Cdc40^em2Jgg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdc40^em2Jgg
• Name: cell division cycle 40; endonuclease-mediated mutation 2, Joseph Gleeson
• MGI ID: MGI:6509469
• Gene: Cdc40 Location: Chr10:40707617-40759139 bp, - strand Genetic Position: Chr10, 22.06 cM, cytoband B1
• Alliance: Cdc40^em2Jgg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using a crRNA (targeting TTCCTTATATCGTTGCAGTT) and tracrRNA with CRISPR/Cas9 technology, an 11 bp deletion was created (NM_027879.2:c.277_287delTTTGGACCAGA), resulting in a frameshift and premature stop codon. (J:300487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc40 Mutation: 37 strains or lines available

References

• Original: J:300487 Chai G, et al., Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron. 2021 Jan 20;109(2):241-256.e9
• All: 1 reference(s)