Pabpn1l^em1Hyfn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pabpn1l^em1Hyfn
• Name: poly(A)binding protein nuclear 1-like; endonuclease-mediated mutation 1, Heng-Yu Fan
• MGI ID: MGI:6509577
• Gene: Pabpn1l Location: Chr8:123346210-123349474 bp, - strand Genetic Position: Chr8, 71.93 cM
• Alliance: Pabpn1l^em1Hyfn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 41-nucleotide deletion in exon 2 (E2). The deletion caused a reading frameshift and created a premature stop codon. (J:302699)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pabpn1l Mutation: 13 strains or lines available

References

• Original: J:302699 Zhao LW, et al., PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition. EMBO Rep. 2020 Aug 5;21(8):e49956
• All: 1 reference(s)