Sfrp4^tm1.1Boer
Targeted Allele Detail

Summary

• Symbol: Sfrp4^tm1.1Boer
• Name: secreted frizzled-related protein 4; targeted mutation 1.1, Derek Boerboom
• MGI ID: MGI:6509974
• Gene: Sfrp4 Location: Chr13:19807345-19816995 bp, + strand Genetic Position: Chr13, 6.99 cM
• Alliance: Sfrp4^tm1.1Boer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275639
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and left the FRT-flanked selection cassette intact. (J:275639)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfrp4 Mutation: 18 strains or lines available

References

• Original: J:275639 Zamberlam G, et al., SFRP4 Is a Negative Regulator of Ovarian Follicle Development and Female Fertility. Endocrinology. 2019 Jul 1;160(7):1561-1572
• All: 1 reference(s)