Ldlrad3^em1Diam
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ldlrad3^em1Diam
• Name: low density lipoprotein receptor class A domain containing 3; endonuclease-mediated mutation 1, Michael S Diamond
• MGI ID: MGI:6509990
• Synonyms: deltaLdlrad3
• Gene: Ldlrad3 Location: Chr2:101780548-102016730 bp, - strand Genetic Position: Chr2, 54.11 cM
• Alliance: Ldlrad3^em1Diam page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was targeted with two sgRNAs (targeting CAGCAACGGGCGGTGCATCC and CGTCACACTGCCAGGCGCCC) using CRISPR/Cas9 technology, resulting in an 11 bp deletion (ATCCCGGGCGC [GCGCCCGGGAT on forward strand]). (J:300132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldlrad3 Mutation: 42 strains or lines available

References

• Original: J:300132 Ma H, et al., LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. Nature. 2020 Dec;588(7837):308-314
• All: 2 reference(s)