Rpl11^tm1.1Srn
Targeted Allele Detail

Summary

• Symbol: Rpl11^tm1.1Srn
• Name: ribosomal protein L11; targeted mutation 1.1, Manuel Serrano
• MGI ID: MGI:6510292
• Synonyms: Rpl11^lox
• Gene: Rpl11 Location: Chr4:135776665-135780704 bp, - strand Genetic Position: Chr4, 68.34 cM
• Alliance: Rpl11^tm1.1Srn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292575
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were flanked by loxP sites and an frt-flanked neomycin cassette was inserted upstream of exon 3. Flp-mediated recombination removed the neomycin cassette and left exons 3-4 floxed. (J:292575)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rpl11 Mutation: 17 strains or lines available

References

• Original: J:292575 Morgado-Palacin L, et al., Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis. Cell Rep. 2015 Oct 27;13(4):712-722
• All: 3 reference(s)