Tg(Syn1-ACE2)#Lazar
Transgene Detail

Summary

• Symbol: Tg(Syn1-ACE2)#Lazar
• Name: transgene insertion, Eric Lazartigues
• MGI ID: MGI:6510603
• Synonyms: SL
• Transgene: Tg(Syn1-ACE2)#Lazar Location: unknown
• Alliance: Tg(Syn1-ACE2)#Lazar page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Syn1-ACE2)#Lazar expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: The human angiotensin-converting enzyme type 2 flanked by loxP sites is under the control of the rat synapsin promoter. RT-PCR shows highest level of expression in the brain and spinal cord. (J:235115)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:235115 Xia H, et al., Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R370-8
• All: 1 reference(s)