Slc10a6^tm1Jmge
Targeted Allele Detail

Summary

• Symbol: Slc10a6^tm1Jmge
• Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 6; targeted mutation 1, Joachim Geyer
• MGI ID: MGI:6510628
• Gene: Slc10a6 Location: Chr5:103753583-103777152 bp, - strand Genetic Position: Chr5, 50.45 cM
• Alliance: Slc10a6^tm1Jmge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neo gene cassette replaced a genomic region including both exons 2 and 3 via homologous recombination. Expression analysis confirmed the absence of mRNA and protein expression in testes from homozygous mice. (J:301761)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc10a6 Mutation: 18 strains or lines available

References

• Original: J:301761 Bakhaus K, et al., Sodium-dependent organic anion transporter (Slc10a6(-/-)) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate. J Steroid Biochem Mol Biol. 2018 May;179:45-54
• All: 1 reference(s)