Nexn^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Nexn^tm1.1Chen
• Name: nexilin; targeted mutation 1.1, Ju Chen
• MGI ID: MGI:6510878
• Gene: Nexn Location: Chr3:151942619-151971987 bp, - strand Genetic Position: Chr3, 77.07 cM
• Alliance: Nexn^tm1.1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted to flank exons 1-4 and an frt-flanked neomycin selection cassette. Exons 1-4 and the the neomycin selection cassette were removed via Cre-mediated recombination in the germline. (J:290931)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nexn Mutation: 28 strains or lines available

References

• Original: J:290931 Liu C, et al., Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation. Circulation. 2019 Jul 2;140(1):55-66
• All: 2 reference(s)