n-TRtct5^tm2.1Slac
Targeted Allele Detail

Summary

• Symbol: n-TRtct5^tm2.1Slac
• Name: nuclear encoded tRNA arginine 5 (anticodon TCT); targeted mutation 2.1, Susan L Ackerman
• MGI ID: MGI:6510888
• Synonyms: B6N-nTr20^-
• Gene: n-TRtct5 Location: Chr1:173217895-173217968 bp, + strand Genetic Position: Chr1, Syntenic
• Alliance: n-TRtct5^tm2.1Slac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted upstream of the locus and a second loxP site downstream. The locus and the neo cassette were deleted through subsequent cre-mediated recombination. (J:297745)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any n-TRtct5 Mutation: 4 strains or lines available

References

• Original: J:297745 Kapur M, et al., Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility. Neuron. 2020 Oct 14;108(1):193-208.e9
• All: 1 reference(s)