Nexn^tm2.1Chen
Targeted Allele Detail

Summary

• Symbol: Nexn^tm2.1Chen
• Name: nexilin; targeted mutation 2.1, Ju Chen
• MGI ID: MGI:6510889
• Synonyms: e3-4del
• Gene: Nexn Location: Chr3:151942619-151971987 bp, - strand Genetic Position: Chr3, 77.07 cM
• Alliance: Nexn^tm2.1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301807
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exons 3-4. The flanked region was deleted via Cre-mediated recombination in the germline. Approximately 20% of truncated Nexn was present with respect to Nexn levels in controls. (J:301807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nexn Mutation: 28 strains or lines available

References

• Original: J:301807 Liu C, et al., Homozygous G650del nexilin variant causes cardiomyopathy in mice. JCI Insight. 2020 Aug 20;5(16)
• All: 1 reference(s)