Spin1^tm1.2Rosc
Targeted Allele Detail

Summary

• Symbol: Spin1^tm1.2Rosc
• Name: spindlin 1; targeted mutation 1.2, Roland Schule
• MGI ID: MGI:6511293
• Gene: Spin1 Location: Chr13:51254916-51306582 bp, + strand Genetic Position: Chr13, 26.04 cM
• Alliance: Spin1^tm1.2Rosc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302851
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT-flanked neomycin resistance gene were inserted upstream of exon 4. An F3-flanked puromycin resistance gene and a second loxP site were inserted downstream of exon 4. Flp-mediated recombination removed the selection cassettes and cre-mediated recombination deleted exon 4. (J:302851)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spin1 Mutation: 101 strains or lines available

References

• Original: J:302851 Greschik H, et al., The histone code reader Spin1 controls skeletal muscle development. Cell Death Dis. 2017 Nov 23;8(11):e3173
• All: 1 reference(s)