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Spin1tm1.2Rosc
Targeted Allele Detail
Summary
Symbol: Spin1tm1.2Rosc
Name: spindlin 1; targeted mutation 1.2, Roland Schule
MGI ID: MGI:6511293
Gene: Spin1  Location: Chr13:51254916-51306582 bp, + strand  Genetic Position: Chr13, 26.04 cM
Alliance: Spin1tm1.2Rosc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:302851
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and an FRT-flanked neomycin resistance gene were inserted upstream of exon 4. An F3-flanked puromycin resistance gene and a second loxP site were inserted downstream of exon 4. Flp-mediated recombination removed the selection cassettes and cre-mediated recombination deleted exon 4. (J:302851)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spin1 Mutation:  101 strains or lines available
References
Original:  J:302851 Greschik H, et al., The histone code reader Spin1 controls skeletal muscle development. Cell Death Dis. 2017 Nov 23;8(11):e3173
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory