Tbc1d21^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tbc1d21^em1Osb
• Name: TBC1 domain family, member 21; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6513081
• Gene: Tbc1d21 Location: Chr9:58266987-58277738 bp, - strand Genetic Position: Chr9, 31.7 cM, cytoband C
• Alliance: Tbc1d21^em1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302631
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted 11,311 bp encompassing exons 1 through 11. (J:302631)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tbc1d21 Mutation: 24 strains or lines available

References

• Original: J:302631 Shimada K, et al., ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2018355118
• All: 2 reference(s)