Rfx7^tm1.1Ggaur
Targeted Allele Detail

Summary

• Symbol: Rfx7^tm1.1Ggaur
• Name: regulatory factor X, 7; targeted mutation 1.1, Greta Guarda
• MGI ID: MGI:6513141
• Synonyms: Rfx7^fl
• Gene: Rfx7 Location: Chr9:72439522-72530111 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Rfx7^tm1.1Ggaur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282535
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 3 and 4 floxed. (J:282535)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx7 Mutation: 78 strains or lines available

References

• Original: J:282535 Castro W, et al., The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity. Nat Immunol. 2018 Aug;19(8):809-820
• All: 1 reference(s)