Zfp998^em1Aiwsk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp998^em1Aiwsk
• Name: zinc finger protein 998; endonuclease-mediated mutation 1, Akiko Iwasaki
• MGI ID: MGI:6513187
• Synonyms: 2410141K09Rik^-
• Gene: Zfp998 Location: Chr13:66566173-66589179 bp, - strand Genetic Position: Chr13, 34.52 cM
• Alliance: Zfp998^em1Aiwsk page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Mutation details: Several gRNAs were used to target this repetitive region using CRISPR/Cas9 technology, resulting in around 6 different genomic deletions. This allele represents a deletion encompassing most of the KRAB type zinc finger protein 998 gene plus downstream intergenic sequence. (J:282526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp998 Mutation: 29 strains or lines available

References

• Original: J:282526 Treger RS, et al., The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV. Immunity. 2019 Feb 19;50(2):334-347.e9
• All: 1 reference(s)