Prss57^tm1.1Gne
Targeted Allele Detail

Summary

• Symbol: Prss57^tm1.1Gne
• Name: serine protease 57; targeted mutation 1.1, Genentech
• MGI ID: MGI:6513231
• Gene: Prss57 Location: Chr10:79617308-79626795 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Prss57^tm1.1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301479
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:301479)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss57 Mutation: 12 strains or lines available

References

• Original: J:301479 AhYoung AP, et al., Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage. Commun Biol. 2020 Nov 19;3(1):687
• All: 1 reference(s)