Eeig1^tm1Soyle
Targeted Allele Detail

Summary

• Symbol: Eeig1^tm1Soyle
• Name: estrogen-induced osteoclastogenesis regulator 1; targeted mutation 1, Soo Young Lee
• MGI ID: MGI:6513232
• Synonyms: EEIG1^-
• Gene: Eeig1 Location: Chr2:32425344-32459763 bp, + strand Genetic Position: Chr2, 22.09 cM
• Alliance: Eeig1^tm1Soyle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303193
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which includes the translation start site, was replaced with a neomycin resistance gene cassette. Western blots and qRT-PCR confirmed the lack of peptide and transcript expression from this allele. (J:303193)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eeig1 Mutation: 14 strains or lines available

References

• Original: J:303193 Jeong E, et al., Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression. FASEB J. 2020 Sep;34(9):12894-12906
• All: 1 reference(s)