Fbxl4^tm1.2Lrsn
Targeted Allele Detail

Summary

• Symbol: Fbxl4^tm1.2Lrsn
• Name: F-box and leucine-rich repeat protein 4; targeted mutation 1.2, Nils-Goran Larsson
• MGI ID: MGI:6514034
• Synonyms: Fbxl4^-
• Gene: Fbxl4 Location: Chr4:22357543-22434091 bp, + strand Genetic Position: Chr4, 9.69 cM
• Alliance: Fbxl4^tm1.2Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303084
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT site flanked puromycin resistance gene cassette were inserted into intron 3 and a second loxP site into intron 4. The puro cassette was removed through subsequent flp-mediated recombination and exon 4 was deleted through cre-mediated recombination. (J:303084)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxl4 Mutation: 31 strains or lines available

References

• Original: J:303084 Alsina D, et al., FBXL4 deficiency increases mitochondrial removal by autophagy. EMBO Mol Med. 2020 Jul 7;12(7):e11659
• All: 1 reference(s)