Tg(Spp1-icre/ERT2)#Lecl
Transgene Detail

Summary

• Symbol: Tg(Spp1-icre/ERT2)#Lecl
• Name: transgene insertion, Isabelle A Leclercq
• MGI ID: MGI:6514326
• Synonyms: OPN-iCre- ER^T2
• Transgene: Tg(Spp1-icre/ERT2)#Lecl Location: unknown
• Alliance: Tg(Spp1-icre/ERT2)#Lecl page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Spp1-icre/ERT2)#Lecl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Spp1 (MGI:98389)

• Mutation details: The mouse was generated via bacterial artificial chromosome transgenesis using the 187kb BAC clone (RP24-327i14) containing the murine Spp1 and Pkd2 genes. Two successive recombinations were performed to insert iCreERT24 in the Spp1 gene and to inactivate the Pkd2 gene. An iCreERT2-polyA-FRTAmpR-FRT fragment was used to insert iCreERT2 in frame and downstream of the initiator ATG of the Spp1 gene. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:303295)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Spp1 (mouse) Summary of all recombinase alleles driven by Spp1. Comparative matrix view of recombinase activities Alliance mouse Spp1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:303295 Espanol-Suner R, et al., Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology. 2012 Dec;143(6):1564-1575.e7
• All: 4 reference(s)