Lypla1^tm1Sem
Targeted Allele Detail

Summary

• Symbol: Lypla1^tm1Sem
• Name: lysophospholipase 1; targeted mutation 1, Clay F Semenkovich
• MGI ID: MGI:6514395
• Gene: Lypla1 Location: Chr1:4878046-4916958 bp, + strand Genetic Position: Chr1, 1.79 cM, cytoband A1
• Alliance: Lypla1^tm1Sem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302677
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 3-5 were flanked by loxP sites. A PGK/neomycin cassette was also inserted between the first loxP site and exon 3. (J:302677)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lypla1 Mutation: 135 strains or lines available

References

• Original: J:302677 Wei X, et al., Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease. Circ Res. 2020 Jul 3;127(2):249-265
• All: 3 reference(s)