Esr1^{tm3.1(flpo)And}
Targeted Allele Detail

Summary

• Symbol: Esr1^{tm3.1(flpo)And}
• Name: estrogen receptor 1 (alpha); targeted mutation 3.1, David Anderson
• MGI ID: MGI:6514725
• Synonyms: Esr1^flp
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^{tm3.1(flpo)And} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303328
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Esr1^{tm3.1(flpo)And} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Esr1 (MGI:1352467)

• Mutation details: The targeting vector contains an attP-F2A-Flp-lox2272-Pgk-Neo-pA-lox2272-attP cassette introduced to the 3' UTR. Cre-mediated recombination removed the floxed neo cassette. (J:303328)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Esr1 (mouse) Summary of all recombinase alleles driven by Esr1. Alliance mouse Esr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:303328 Karigo T, et al., Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice. Nature. 2021 Jan;589(7841):258-263
• All: 2 reference(s)