Lrrc25^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc25^em1Cya
• Name: leucine rich repeat containing 25; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6514757
• Synonyms: Lrrc25^em1Cgen
• Gene: Lrrc25 Location: Chr8:71068810-71073501 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Lrrc25^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology was used to delete exons 2-3. (J:270157)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc25 Mutation: 18 strains or lines available

References

• Original: J:270157 Zhang X, et al., Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-beta1. Biochem Biophys Res Commun. 2018 Nov 17;506(1):137-144
• All: 1 reference(s)