Mrs2^em1Muma
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mrs2^em1Muma
• Name: MRS2 magnesium transporter; endonuclease-mediated mutation 1, Muniswamy Madesh
• MGI ID: MGI:6514834
• Synonyms: Mrs2^-
• Gene: Mrs2 Location: Chr13:25171466-25204345 bp, - strand Genetic Position: Chr13, 10.83 cM
• Alliance: Mrs2^em1Muma page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: Exon 8 was targeted using two gRNAs and an ssODN template with CRISPR/Cas9 technology, resulting in a premature stop codon (TAA) in place of an alanine codon at position 280 (GCA) (p.A280*). (J:298361)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrs2 Mutation: 23 strains or lines available

References

• Original: J:298361 Daw CC, et al., Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular Metabolism. Cell. 2020 Oct 15;183(2):474-489.e17
• All: 3 reference(s)