Hmgcr^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hmgcr^em1Bcgen
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:6515596
• Synonyms: HMGCR(K248R), Hmgcr^KI
• Gene: Hmgcr Location: Chr13:96785475-96807444 bp, - strand Genetic Position: Chr13, 50.65 cM
• Alliance: Hmgcr^em1Bcgen page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting produced the amino acid substitution of lysine with arginine at position 248 (K248R). (J:299971)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgcr Mutation: 62 strains or lines available

References

• Original: J:299971 Lu XY, et al., Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. Nature. 2020 Dec;588(7838):479-484
• All: 1 reference(s)