Sardh^em1Tzq
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sardh^em1Tzq
• Name: sarcosine dehydrogenase; endonuclease-mediated mutation 1, Zhiqian Tong
• MGI ID: MGI:6515833
• Gene: Sardh Location: Chr2:27078405-27138344 bp, - strand Genetic Position: Chr2, 19.31 cM
• Alliance: Sardh^em1Tzq page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: CRISPR-targeting with a donor plasmid inserted upstream of exon 11 an FRT site, splice acceptor, IRES, lacZ reporter gene, polyadenylation sequence, loxP site, hbactp promoter driving a neomycin resistance cassette, polyadenylation sequence, FRT site, and loxP site. An additional loxP site was inserted downstream of exon 11. (J:285251)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sardh Mutation: 62 strains or lines available

References

• Original: J:285251 Ai L, et al., Endogenous formaldehyde is a memory-related molecule in mice and humans. Commun Biol. 2019;2:446
• All: 1 reference(s)