Slc6a7^tm1Veul
Targeted Allele Detail

Summary

• Symbol: Slc6a7^tm1Veul
• Name: solute carrier family 6 (neurotransmitter transporter, L-proline), member 7; targeted mutation 1, Volker Eulenburg
• MGI ID: MGI:6682116
• Gene: Slc6a7 Location: Chr18:61128452-61147294 bp, - strand Genetic Position: Chr18, 34.41 cM, cytoband E1
• Alliance: Slc6a7^tm1Veul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288931
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.15 kb region including exons 6 and 7 was replaced with a pgk-neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of mRNA and protein in forebrain regions from homozygous mice. (J:288931)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a7 Mutation: 34 strains or lines available

References

• Original: J:288931 Schulz D, et al., Inactivation of the Mouse L-Proline Transporter PROT Alters Glutamatergic Synapse Biochemistry and Perturbs Behaviors Required to Respond to Environmental Changes. Front Mol Neurosci. 2018;11:279
• All: 1 reference(s)