Jazf1^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Jazf1^{tm1c(EUCOMM)Wtsi}
• Name: JAZF zinc finger 1; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6690297
• Synonyms: Jazf1^fl
• Gene: Jazf1 Location: Chr6:52745782-53045616 bp, - strand Genetic Position: Chr6, 25.74 cM
• Alliance: Jazf1^{tm1c(EUCOMM)Wtsi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303318
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 52788833 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 52789727. Exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying the tm1a allele. (J:303318)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jazf1 Mutation: 22 strains or lines available

References

• Original: J:303318 Kobiita A, et al., The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress. Cell Rep. 2020 Jul 7;32(1):107846
• All: 1 reference(s)