Aplnr^{em3(cre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aplnr^{em3(cre/ERT2)Smoc}
• Name: apelin receptor; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
• MGI ID: MGI:6690419
• Synonyms: Apj-CreER
• Gene: Aplnr Location: Chr2:84966704-84970267 bp, + strand Genetic Position: Chr2, 49.45 cM, cytoband E1
• Alliance: Aplnr^{em3(cre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Aplnr^{em3(cre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aplnr (MGI:1346086)

• Mutation details: Using the CRISPR/Cas9 technology cre/ERT2 cassette was targeted to the translational start codon ATG of the mouse Aplnr gene via homologous recombination. (J:270635)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aplnr (mouse) Summary of all recombinase alleles driven by Aplnr. Comparative matrix view of recombinase activities Alliance mouse Aplnr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aplnr Mutation: 30 strains or lines available

References

• Original: J:270635 Zhao H, et al., Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target. Cell Rep. 2018 Oct 30;25(5):1241-1254.e5
• All: 3 reference(s)