Phf7^em2Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Phf7^em2Osb
• Name: PHD finger protein 7; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6690454
• Synonyms: Phf7^CA, Phf7^{em2(C160A)Osb}
• Gene: Phf7 Location: Chr14:30959646-30973274 bp, - strand Genetic Position: Chr14, 19.09 cM
• Alliance: Phf7^em2Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298823
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 7 produced the amino acid substitution of cysteine with alanine at position 160 (TGT to GCT; C160A). (J:298823)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phf7 Mutation: 27 strains or lines available

References

• Original: J:298823 Kim CR, et al., PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis. Cell Rep. 2020 Jul 28;32(4):107950
• All: 1 reference(s)